Several peyote cactus buttons. The main peyote cactus on the picture is actually blossoming.

Simon’s Peyote Guide

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Peyote (Lophophora williamsii) is a small cactus native to Mexico and Texas. Unlike many other cacti species, peyote cacti do not have spines. The plants are small and round, often referred to as buttons.

The name peyote stems from the Nahuatl (Aztec) name peyōtl meaning glisten or glistening. This name most likely refers to the psychoactive effects of the cactus.

Peyote cacti have been used for over 5000 years, mainly for its psychoactive properties. The effects of the cactus were known to several indigenous and Native American tribes, who used the plants in shamanistic rituals.

Peyote is one of the main deities of the Huichol religion, along with Blue Deer, Corn and Eagle. Huichol, referring to themselves as Wixáritari are native Mexicans who collect peyote once every year, and use them to assume the role of their gods.


A very big, flowering peyote cactus (two pink flowers).
Peyote cactus

Effects of the peyote:

Lophophora williamsii is one of the cacti native to the Americas that contains mescaline. In fact, peyote contains the largest concentration of mescaline among the mescaline cacti (other species include San Pedro cactus, the Peruvian and the Bolivian torch).

The main active ingredient in peyote is mescaline, which has psychoactive and hallucinogenic effects. Apart from mescaline, peyote also contains hordenine.

Mescaline can induce a variety of physical, cognitive and visual effects. Visual hallucinations can range from enhanced colours and brightness to geometric forms and complex fractals.

Mescaline has also been used for various medicinal reasons. However, because of its restricted nature, there have been relatively few studies researching the healing properties of peyote cacti.


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Peyote guide




 Peyote – legal status


Peyote is a controlled plant in several countries because of its mescaline content. Extraction and possession of mescaline itself is generally illegal.

Still, several countries allow the possession and cultivation of live peyote cacti in some way. In these areas, the cacti may be grown for either decorative or religious reasons.


Let’s see a country-by-country breakdown: 

 Peyote – legal status
USAPeyote is a schedule I substance in the US, illegal to trade, possess, buy or cultivate. However, the law recognises the Native American Church, and cacti with mescaline content are legal for bona fide religious use. These laws vary from state to state, but peyote is legal in some form in:  Arizona, Colorado, Idaho, Iowa, Kansas, Minnesota, Nevada, New Mexico, Oklahoma, Oregon, South Dakota, Texas, Wisconsin and Wyoming.
AustraliaMescaline is a controlled substance in Australia, and cacti with mescaline content are illegal to import. Peyote itself is controlled in the Australian Capital Territory, and possibly in other states as well.
CanadaMescaline is a controlled substance in Canada, but peyote itself is legal. Preparations of the cactus may be considered mescaline and thus banned, but the plant itself may be possessed freely.
FrancePeyote is on the list of controlled substances, and is illegal in France.
MexicoPeyote is a scheduled substance in Mexico, and it is also considered an endangered species. As a result, it is illegal to harvest for everyone but some indigenous tribes.
NetherlandsMescaline is a controlled substance in Canada, but peyote itself is legal. Preparations of the cactus may be considered mescaline and thus banned, but the plant itself may be possessed freely.


Peyote is available for buying in South Korea for decorational, ornamental reasons.
UKPlants with mescaline content, including peyote, are not controlled in the UK. Mescaline is a controlled substance, but there is no law banning preparations of peyote.



Buy Peyote


Buy Peyote – US

I can’t personally recommend any US vendors right now.


Buy Peyote – Europe, Netherlands

I recommend buying Peyote at the following link:

Buy peyote  /Shipped from the Netherlands./


Peyote effects


The main psychoactive compound present in peyote cacti is the alkaloid mescaline. Mescaline is a psychedelic, hallucinogenic substance with widespread recreational use.

The molecular structure of mescaline, 3,4,5-trimethoxyphenethylamine.
Structure of mescaline

Mescaline, or 3,4,5-trimethoxyphenethylamine is a serotonergic psychedelic, which means it exerts its effects through activating the  serotonin 5-HT2A receptor with a high affinity. However, exactly how this results in the psychedelic effects is yet unclear.

Peyote also contains hordenine, an alkaloid that is a selective substrate for MAO-B. This compound can act as an inhibitor, preventing the body from metabolising mescaline too fast, contributing to the cactus’ effectiveness.

Cognitive effects

Peyote and other sources of mescaline induce an altered state of consciousness while accelerating the thought process and enhancing the analytic capabilities. The state induced by mescaline is more lucid and clear than that of LSD.

Although conceptual thinking is enhanced, mescaline use may also cause disorganised thinking, delusions, and a distorted sense of time.

As with most psychedelics, mescaline causes short term memory suppression, which can lead to a disassociation from one’s self and ego death. Mescaline use is considered by many to be a spiritual experience.

Most psychonauts who consume peyote describe it as a positive experience. Mescaline can cause euphoria, but some users have also reported enhanced feelings of anxiety.

The visual hallucinations are likely the most sought-after effects caused by cacti with mescaline content. Hallucinations can include simple geometric patterns and whole scenarios as well.

Visions are often considered spiritual, mystical or religious in their nature. Generally described as a positive experience, however, some users have reported seeing unspeakable horrors as well.


Physical effects

Mescaline acts as a stimulant, making users feel more energetic and motivating them to participate in various physical activities such as running or dancing. Users have stronger, more precise control over their bodies.

Other physical effects that can be caused by peyote include wakefulness, dilated pupils and increased heart rate. Nausea is among the more unpleasant effects caused by mescaline.


After effects

It takes about 40 minutes to experience the primary effects of mescaline, which usually last for 8-12 hours. After effects are normally experienced for about 24 hours after the consumption.

After effects of mescaline include joint stiffness, muscle aches and physical tiredness. This is the result of the body returning to its normal state from elevated blood pressure and the stimulating effect of mescaline.

Some users have reported a vague sense of confusion and an indescribable “afterglow” from the effects. Insomnia is common even after the primary effects have faded.


Sources: Drugs.comPsychonautWiki


Dangers of Peyote


Cacti containing mescaline are generally considered safe compared to other psychedelic substances. In the 5000 years humans have used mescaline, there have been no reported case of a lethal overdose.

Cacti with mescaline content such as peyote also cause no physical addiction, though psychological addiction is always a possibility. Peyote users have no memory problems when studied along with those with minimal to no substances used.

Peyote, and mescaline in general, does have a few side-effects though. Nausea is common after consumption, and some users reported strong feelings of anxiety as well.



Peyote health benefits


Cacti with mescaline content have been consumed for their supposed healing properties for thousands of years. However, because of mescaline’s status as a controlled substance, relatively little research has been done to support or contradict these claims.

The consumption of mescaline is traditionally considered to be a spiritual or religious experience. Users are said to reach a deeply introspective state with enhanced thought processes.

Apart from its psychedelic nature, peyote has also been used to cure several ailments such as toothache, fever, pain, diabetes and asthma. However, evidence regarding such healing effects is severely lacking.



Peyote preparation and consumption


The mescaline content of dried peyote cacti is generally about 1-2%. However, the concentration varies greatly from plant to plant, and can reach 5-6% as well. Because of this, caution should always be exercised when trying larger doses.

The threshold amount for peyote is about 3 mid-sized fresh “buttons” (50 g), which is equivalent to 10 grams of dried cacti. Average dosage is between 6 and 12 pieces, while anything above 15 is considered a heavy dose.

Peyote cacti may be prepared and consumed in a number of ways. Perhaps the most common way of ingesting peyote is simply chewing the buttons.

Pyote may also be consumed in the form of a tea, steeping the buttons in hot water for a rather long time, then drinking the concoction.

According to one psychonaut, the most effective way of consumption is as follows. The buttons are washed and the “spines” as well as the skin are removed. Make sure to remove as little of the plant’s flesh as possible.

Cut the sections of tissue off the core and place them in the freezer for a few hours. Afterwards, grind the frozen sections and then filter the pulp, collecting the liquid and adding a bit of water. Try to get all the liquid from the plant.

Source: Recipe

The solid or liquid cactus can be consumed after preparation. The plant is reported to taste rather unpleasant in all its forms. Having pineapple juice, or some other chaser with a strong taste at hand might help.


Buy Peyote


Buy Peyote – US

I can’t personally recommend any US vendors right now.


Buy Peyote – Netherlands

You can buy Peyote at the following link:

Buy peyote  /Shipped from the Netherlands./


Peyote trip reports


The following are peyote trip reports of various people from various websites.

“1 Hour to 2 hours, I start to feel a lot of nausea, but I don’t feel like puking, I probably would have if I would have made any sudden moves. I start noticing my thoughts start to move around more and they start to come alive, when I close my eyes I start to see blue, orange, Green, and red designs that are very brightly colored.

The designs that I start to see are very geometrical, and I start to even see the designs starting to form people and objects along with other things.

I start seeing other people’s thoughts expressed to me in the form of dreams, I see intricate details of people, things that they only know. I start hearing people talk to me in the dreams. I start flying to the universe and I see bright bright colors now, the designs move slowly and not fast contantly changing like mushrooms do to me.

 I start to receive info about my life and how to become a better person, I learn ways on how to be in life, humble, loving. How to pray better, how to heal, how to find a better job, right decisions. I moved around into different worlds and different thoughts.

– Excerpts from Peyote Healer’s peyote trip report


If you find this Peyote guide useful please give it a “+1”: 

Thank you!

Share your own trip report in the comment section below (to ensure anonymity don’t use your real name or real email address when submitting trip reports)!

Some of the information presented here might be outdated or incorrect (check “last updated” below). If you are planning to try out any of the substances, make sure to to research them yourself as well.

I’m 100% committed to safe and responsible legal high consumption. If you have a few minutes to spare please read my blog post about responsible and safe legal drugs use.

Peyote is only one of the legal highs included in Simon’s legal high guide, check out the others as well.

If you are only interested in legal psychedelics, then check out Simon’s Legal Psychedelics for more.

Last updated: 2015. 11. 27.

Simon's Peyote (Lophophora Williamsii) Guide
Article Name
Simon's Peyote (Lophophora Williamsii) Guide
A guide detailing the properties, effects and legal status of peyote with peyote trip reports included.

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